| Gene Symbol |
PIK3R1
|
| Gene Synonyms |
p85 AGM7 GRB1 IMD36 p85alpha p85-ALPHA |
| Gene Full Name |
phosphoinositide-3-kinase regulatory subunit 1 |
| Gene Summary |
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] |
| Molecular Weight(MW) |
85kDa |
| Cellular Localization |
Cytosol, Membrane, Nucleus. |