ELISA
Coat the plate with immunizing antigen.Blue line： Immune serum; Orange line: Pre-immune serum.| Product Name | Anti-MLH1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISA |
| ELISA:1:1000-1:10000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | MLH1 |
|---|---|
| Gene Synonyms | 1110035C23Rik COCA2 FCC2 hMLH1 HNPCC HNPCC2 LYNCH2 MLH-1 MMRCS1 |
| Gene Full Name | mutL homolog 1 |
| Gene Summary | The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017] |
| Alternative Names | colon cancer nonpolyposis type 2 DNA mismatch repair protein MutL homolog human homolog of E. coli mutL gene product Swiss-Prot Accession Number P23367 MGC5172 mismatch repair protein 1 MLH-1 MLH1 mutL homolog 1 colon cancer nonpolyposis type 2 mutL protein homolog 1 |
| Molecular Weight(MW) | 85kDa |
| Source | Rabbit |
| Cellular Localization | Nucleus |
| SwissProt ID | P40692 |
|---|
ELISA
Coat the plate with immunizing antigen.Blue line： Immune serum; Orange line: Pre-immune serum.| Application Notes | ELISA:1:1000-1:10000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
