The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Alternative Names
1-phosphatidyl-D-myo-inositol-4 5-bisphosphate inositoltrisphosphohydrolase monophosphatidylinositol phosphodiesterase phosphoinositidase C phosphoinositide phospholipase C phosphoinositide phospholipase C-beta-1 phosphoinositide-specific phospholipase c phospholipase C beta 1 (phosphoinositide-specific) phospholipase C-1 phospholipase C-beta-1a Phospholipase C-beta1 phospholipase C-I PLC-154 PLC-beta-1 PLC-I triphosphoinositide phosphodiesterase