| Product Name | Anti-HER3/ErbB3 antibody-RBITC |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | RBITC |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | ERBB3 |
|---|---|
| Gene Synonyms | c-erbB-3 c-erbB3 ErbB-3 erbB3-S Erbb3r FERLK HER3 LCCS2 MDA-BF-1 nuc-ErbB3 p180-ErbB3 p45-sErbB3 p85-sErbB3 VSCN1 |
| Gene Full Name | erb-b2 receptor tyrosine kinase 3 |
| Gene Summary | This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
| Alternative Names | avian erythroblastosis oncogene B 3 avian erythroblastosis oncogene B 3 receptor c-erbB-3 c-erbB3 C-errB-3 epidermal growth factor receptor precursor erbB3 glial growth factor receptor HER3 protein precursor human epidermal growth factor receptor 3 MDA BF 1 MGC88033 p180 ErbB3 p45 sErbB3 p85 sErbB3 proto-oncogene-like protein c-ErbB-3 receptor tyrosine kinase tyrosine kinase-type cell surface receptor HER3 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 |
| Molecular Weight(MW) | 148kDa |
| Source | Rabbit |
| Cellular Localization | Cell membrane, Secreted |
| SwissProt ID | P21860 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
