| Product Name | Anti-Phospho-HER3/ErbB3 (Tyr1289) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Tyr1289 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ERBB3 |
|---|---|
| Gene Synonyms | HER3 FERLK LCCS2 VSCN1 ErbB-3 c-erbB3 erbB3-S MDA-BF-1 c-erbB-3 p180-ErbB3 p45-sErbB3 p85-sErbB3 |
| Gene Full Name | erb-b2 receptor tyrosine kinase 3 |
| Gene Summary | This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
| Alternative Names | c erbB 3 c erbB3 Erb b2 receptor tyrosine kinase 3 ErbB 3 ERBB3 ERBB3 protein erbB3 S ERBB3_HUMAN Glial growth factor receptor HER 3 HER3 Human epidermal growth factor receptor 3 LCCS2 MDA BF 1 MGC88033 p180 ErbB3 p45 sErbB3 p85 sErbB3 proto-oncogene-like protein c ErbB 3 proto-oncogene-like protein c ErbB3 Proto-oncogene-like protein c-ErbB-3 Receptor tyrosine protein kinase erbB 3 Receptor tyrosine protein kinase erbB3 Receptor tyrosine-protein kinase erbB-3 Tyrosine kinase type cell surface receptor HER3 Tyrosine kinase-type cell surface receptor HER3 v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) v erb b2 erythroblastic leukemia viral oncogene homolog 3 |
| Molecular Weight(MW) | 148 kDa |
| Cellular Localization | Cell membrane,Membrane,Secreted. |
| SwissProt ID | P21860 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
