ICC/IF
Immunofluorescence analysis of C2C12 cells using IL7 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Product Name | Anti-IL7 antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | IL7 |
|---|---|
| Gene Synonyms | A630026I06Rik CD127 CDW127 hlb368 IL-7 IL-7R-alpha IL-7Ralpha IL7RA IL7Ralpha ILRA IMD104 IMD130 lnc-IL7R sIL-7R |
| Gene Full Name | interleukin 7 |
| Gene Summary | The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. IL7 plays an essential role in lymphoid cell survival, and in the maintenance of naive and memory T cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can be a potent inducer of proinflammatory cytokines and chemokines which may defend against the infection, but may also mediate destructive lung injury. Elevated serum IL7 levels, together with several other circulating cytokines and chemokines, has been found to be associated with the severity of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Jul 2020] |
| Alternative Names | CD127 antigen cytokine H-IL-7 IL-7 IL-7 receptor alpha chain IL-7 receptor subunit alpha IL-7R subunit alpha IL-7R-alpha IL-7RA IL7R IL-7 receptor alpha chain ILN Interleukin interleukin 7 precursor interleukin 7 receptor alpha chain interleukin-7 receptor precursor Interleukin7 M-IL-7 soluble interleukin-7 receptor |
| Molecular Weight(MW) | 20kDa(observed：24kDa) |
| Cellular Localization | Secreted |
| SwissProt ID | P13232 |
|---|
ICC/IF
Immunofluorescence analysis of C2C12 cells using IL7 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
