ICC/IF
Immunofluorescence analysis of NIH3T3 cells using GRM8 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Product Name | Anti-GRM8 antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | GRM8 |
|---|---|
| Gene Synonyms | A230002O04 GLUR8 GPRC1H mGlu8 mGlur MGLUR8 mGluR8b |
| Gene Full Name | glutamate metabotropic receptor 8 |
| Gene Summary | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| Alternative Names | FLJ41058 G protein coupled receptor family C group 1 member H G protein-coupled receptor family C group 1 member H G-protein coupled receptor glutamate receptor glutamate receptor metabotropic 8 M mGlu8 metabotropic glutamate receptor subtype 8b MGC126724 |
| Molecular Weight(MW) | 102kDa |
| Cellular Localization | Cell membrane |
| SwissProt ID | O00222 |
|---|
ICC/IF
Immunofluorescence analysis of NIH3T3 cells using GRM8 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
