ICC/IF
Immunofluorescence analysis of NIH3T3 cells using TNFRSF18 antibody (green). Blue: DAPI fluorescent DNA dye.Cells are fixed in 4% paraformaldehyde at room temperature for 15 minutes.| Product Name | Anti-TNFRSF18 antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | TNFRSF18 |
|---|---|
| Gene Synonyms | AITR CD357 ENERGEN GITR GITR-D |
| Gene Full Name | TNF receptor superfamily member 18 |
| Gene Summary | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011] |
| Alternative Names | activation-inducible TNFR family receptor AITR GITR TNF receptor homolog similar to murine glucocorticoid-induced TNFR-related protein glucocorticoid-induced TNFR-related protein PRO364 TNF receptor superfamily activation-inducible protein tumor necrosis factor receptor superfamily member 18 UNQ319 variant (4) contains an extra coding segment which leads to a frame shift compared to variant 1 and 3 resulting protein (isoform 4) contains a transmembrane domain (identical to variant 1 and 3) and a longer cytoplasmic domain with a sequence different |
| Molecular Weight(MW) | 26kDa(observed：35kDa) |
| Cellular Localization | Cell membrane |
| SwissProt ID | Q9Y5U5 |
|---|
ICC/IF
Immunofluorescence analysis of NIH3T3 cells using TNFRSF18 antibody (green). Blue: DAPI fluorescent DNA dye.Cells are fixed in 4% paraformaldehyde at room temperature for 15 minutes.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
