This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
Alternative Names
activation-inducible TNFR family receptor AITR GITR TNF receptor homolog similar to murine glucocorticoid-induced TNFR-related protein glucocorticoid-induced TNFR-related protein PRO364 TNF receptor superfamily activation-inducible protein tumor necrosis factor receptor superfamily member 18 UNQ319 variant (4) contains an extra coding segment which leads to a frame shift compared to variant 1 and 3 resulting protein (isoform 4) contains a transmembrane domain (identical to variant 1 and 3) and a longer cytoplasmic domain with a sequence different