This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
Alternative Names
a disintegrin and metalloprotease domain 8 a disintegrin and metalloproteinase a disintegrin and metalloproteinase domain 8 ADAM ADAMs cell surface antigen MS2 human leukocyte differentiation antigen macrophage cysteine-rich glycoprotein metalloendopeptidases MGC134985