ICC/IF
Immunofluorescence analysis of NIH3T3 cells using ATP7A antibody (green). Blue: DAPI fluorescent DNA dye.Cells are fixed in 4% paraformaldehyde at room temperature for 15 minutes.IF-P
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using ATP7A antibody with DAB staining.IF-P
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using ATP7A antibody with DAB staining.| Product Name | Anti-ATP7A antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | ATP7A |
|---|---|
| Gene Synonyms | DSMAX HMNX MK MNK SMAX3 |
| Gene Full Name | ATPase copper transporting alpha |
| Gene Summary | This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. [provided by RefSeq, Aug 2013] |
| Alternative Names | ATP 7A ATP7A ATPase Cu++ transporting alpha polypeptide copper efflux transporter copper pump 1 Cu++-transporting P-type ATPase FLJ17790 MC 1 Menke Menkes disease-associated protein menkes disease-associated protein homolog Menkes protein Menkes syndrome OHS OTTHUMP00000062077 Wilson disease gene |
| Molecular Weight(MW) | 163kDa |
| Cellular Localization | Golgi apparatus, trans-Golgi network membrane;Cell membrane;Early endosome membrane;Cell projection, axon;Cell projection, dendrite;Postsynaptic density;Cytoplasm, cytosol;Endoplasmic reticulum |
| SwissProt ID | Q04656 |
|---|
ICC/IF
Immunofluorescence analysis of NIH3T3 cells using ATP7A antibody (green). Blue: DAPI fluorescent DNA dye.Cells are fixed in 4% paraformaldehyde at room temperature for 15 minutes.
IF-P
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using ATP7A antibody with DAB staining.
IF-P
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using ATP7A antibody with DAB staining.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
