This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Alternative Names
(intestinal Kruppel-like factor basic transcription element binding protein 2 basic transcription element binding protein BTEB2 basic transcription element-binding protein 2 BTE-binding protein 2 colon krueppel-like factor colon kruppel-like factor epididymis secretory sperm binding protein GC box binding protein 2 intestinal-enriched krueppel-like factor intestinal-enriched kruppel-like factor Kruppel like factor 5 Kruppel-like factor 5 Kruppel-like factor 5 (intestinal) RP11-505F3.5 testis-specific transcript tKLF5 transcription factor transcription factor BTEB2