ICC/IF
Immunofluorescence analysis of SK-N-SH cells using MAP4K4 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Product Name | Anti-MAP4K4 antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | MAP4K4 |
|---|---|
| Gene Synonyms | 9430080K19Rik FLH21957 HEL-S-31 HGK MEKKK4 NIK |
| Gene Full Name | mitogen-activated protein kinase kinase kinase kinase 4 |
| Gene Summary | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| Alternative Names | epididymis secretory protein Li 31 FLJ10410 FLJ20373 FLJ90111 hepatocyte progenitor kinase-like/germinal center kinase-like kinase HPK/GCK-like kinase HGK MAPK/ERK kinase kinase kinase 4 MEK kinase kinase 4 MEKKK 4 NCK interacting kinase nck-interacting kinase Ste20 group protein kinase HGK tumor-associated splice form |
| Molecular Weight(MW) | 142kDa |
| Source | Rabbit |
| Cellular Localization | Cytoplasm |
| SwissProt ID | O95819 |
|---|
ICC/IF
Immunofluorescence analysis of SK-N-SH cells using MAP4K4 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
