mitogen-activated protein kinase kinase kinase kinase 4
Gene Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Alternative Names
epididymis secretory protein Li 31 FLJ10410 FLJ20373 FLJ90111 hepatocyte progenitor kinase-like/germinal center kinase-like kinase HPK/GCK-like kinase HGK MAPK/ERK kinase kinase kinase 4 MEK kinase kinase 4 MEKKK 4 NCK interacting kinase nck-interacting kinase Ste20 group protein kinase HGK tumor-associated splice form