ICC/IF
Immunofluorescence analysis of Hela cells using MBNL1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Product Name | Anti-MBNL1 antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | MBNL1 |
|---|---|
| Gene Synonyms | EXP MBNL mKIAA0428 |
| Gene Full Name | muscleblind like splicing regulator 1 |
| Gene Summary | This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities. [provided by RefSeq, Sep 2015] |
| Alternative Names | 35 kDa CUG triplet repeat expansion dsRNA-binding protein C3H type zinc finger protein C3H zinc finger dsRNA-binding protein C3H Zn finger dsRNA binding protein DKFZp686P06174 EXP35 EXP40 EXP42 KIAA0428 muscleblind like splicing factor 1 muscleblind-like muscleblind-like 1 triplet-expansion RNA-binding protein zinc finger protein |
| Molecular Weight(MW) | 41kDa（observed：53kDa) |
| Source | Rabbit |
| Cellular Localization | Nucleus;Cytoplasm;Cytoplasmic granule |
| SwissProt ID | Q9NR56 |
|---|
ICC/IF
Immunofluorescence analysis of Hela cells using MBNL1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
