ICC/IF
Immunofluorescence analysis of A549 cells using SMAD7 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Product Name | Anti-SMAD7 antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | SMAD7 |
|---|---|
| Gene Synonyms | CRCS3 MADH7 MADH8 |
| Gene Full Name | SMAD family member 7 |
| Gene Summary | The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| Alternative Names | FLJ16482 hSMAD7 MAD (mothers against decapentaplegic Drosophila) homolog 7 Mad homolog MAD homolog 7 MAD homolog 8 madh8 mothers against decapentaplegic homolog 7 mothers against decapentaplegic homolog 8 Mothers against decapentaplegic drosophila homolog of 7 mothers against DPP homolog 7 mothers against DPP homolog 8 SMAD SMAD 7 SMAD mothers against DPP homolog 7 |
| Molecular Weight(MW) | 46kDa（observed：53kDa) |
| Source | Rabbit |
| Cellular Localization | Nucleus;Cytoplasm |
| SwissProt ID | O15105 |
|---|
ICC/IF
Immunofluorescence analysis of A549 cells using SMAD7 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
