transformation/transcription domain associated protein
Gene Summary
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Alternative Names
350/400 kDa PCAF-associated factor OTTHUMP00000197294 OTTHUMP00000197295 similar to ATM/DNA-PK tra1 homolog transactivation/transformation-domain associated protein