This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
Alternative Names
52 kDa ribonucleoprotein autoantigen Ro/SS-A 52 kDa Ro protein 52-kD Ro/SSA ribonucleoprotein 52kD Ro/SSA autoantigen 52kDa ribonucleoprotein autoantigen SS-A/Ro RING finger protein 81 RING-type E3 ubiquitin transferase TRIM21 ro(SS-A) Ro/SSA 52kDa Sicca syndrome antigen A sjoegren syndrome type A antigen Sjogren syndrome antigen A1 Sjogren syndrome antigen A1 (52kDa ribonucleoprotein autoantigen SS-A/Ro) SS-A Trim21 tripartite motif protein 21 tripartite motif-containing protein 21