The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Alternative Names
1-phosphatidyl-D-myo-inositol-4 5-bisphosphate cell differentiation and embryonic development EC 3.1.4.11 inositoltrisphosphohydrolase monophosphatidylinositol phosphodiesterase OTTHUMP00000178982 phosphatidylinositol phospholipase C phosphoinositidase C phosphoinositide phospholipase C phosphoinositide phospholipase C-gamma-1 phospholipase C phospholipase C gamma 1 (formerly subtype 148) phospholipase C-1 phospholipase C-148 phospholipase C-gamma phospholipase C-II Phospholipase C2 PLC gamma1 PLC-148 PLC-gamma-1 PLC-II PLC2I similar to PLC gamma 1 triphosphoinositide phosphodiesterase