protein kinase AMP-activated non-catalytic subunit beta 2
Gene Summary
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
Alternative Names
5'-AMP-activated protein kinase 40 kDa subunit 5'-AMP-activated protein kinase beta-1 subunit 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-1-like protein 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase beta subunit 5'-AMP-activated protein kinase beta-2 subunit 5-AMP-activated protein kinase beta subunit AMP-activated protein kinase beta 2 non-catalytic subunit AMP-activated protein kinase beta subunit AMP-activated protein kinase beta-2 regulatory subunit AMPK beta -1 chain AMPK beta 1 AMPK beta 2 AMPK beta-1 chain AMPK beta-2 chain AMPK subunit beta-1 AMPK subunit beta-2 AMPKb non-catalytic subunit protein kinase AMP-activated beta 1 non-catalytic subunit protein kinase AMP-activated beta 2 non-catalytic subunit protein kinase AMP-activated noncatalytic beta-1
Molecular Weight(MW)
30kDa
Source
Rabbit
Cellular Localization
cytoplasm;cytosol;endoplasmic reticulum lumen;nucleoplasm;nucleotide-activated protein kinase complex;nucleus;Complete GO annotation on QuickGO