This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]
Alternative Names
BD73 EAR-1 EAR-1R NR1D1 nuclear receptor protein nuclear receptor Rev-ErbA-alpha orphan nuclear receptor rev-erb alpha Rev-erba rev-erbA alpha rev-erbA-alpha Rev-ErbA-alpha protein Rev-ErbAalpha REV-ERBalpha Reverbaalpha RVR V-erbA-related protein 1 V-erbA-related protein EAR-1