This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and binds to mannose and N-acetylglucosamine on many microorganisms, including bacteria, yeast, and viruses including influenza virus, HIV and SARS-CoV. This binding activates the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jun 2020]
Alternative Names
activates complement system collectin-1 Collectin1 liver regeneration-related protein LRRG037 liver regeneration-related protein LRRG053 mannan-binding lectin mannan-binding protein mannose binding lectin 2 (protein C) mannose binding lectin liver (C) mannose-binding lectin (protein C) 2 mannose-binding lectin (protein C) 2 soluble (opsonic defect) mannose-binding lectin 2 soluble (opsonic defect) mannose-binding protein C (liver) mannose-binding protein C precursor mannose-binding protein C-like MBP-C MBPC MGC116832 MGC116833 RA-reactive factor P28A subunit ra-reactive factor polysaccharide-binding component p28A raRF p28A RARF/P28A