Enables cation binding activity; histone H3K14ub reader activity; and histone H3K9 trimethyltransferase activity. Involved in epigenetic programming in the zygotic pronuclei and pericentric heterochromatin formation. Acts upstream of or within cellular response to hypoxia and negative regulation of transcription by RNA polymerase II. Located in chromatin. Is active in nucleus and pericentric heterochromatin. [provided by Alliance of Genome Resources, Jun 2026]