This gene encodes the cardiac isoform of troponin T. The encoded protein is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. [provided by RefSeq, May 2022]
Alternative Names
alternatively spliced cardiac muscle troponin T cardiac TnT cardiac troponin T cardiac troponin T2 cardiomyopathy dilated 1D (autosomal dominant) cardiomyopathy hypertrophic 2 cTnT MGC3889 tnTc troponin T Troponin T cardiac troponin T type 2 (cardiac) Troponin T2
Molecular Weight(MW)
35kDa
Source
Rabbit
Cellular Localization
cardiac myofibril;cardiac Troponin complex;cytosol;sarcomere;striated muscle thin filament;troponin complex;Complete GO annotation on QuickGO