This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Alternative Names
avian sarcoma virus CT10 (v-crk) oncogene homolog CRK-II Crk3 CSAID-binding protein Csaids binding protein CT-10 related kinase 3 cytokine suppressive anti-inflammatory drug binding protein cytokine-supressive anti-inflammatory drug binding protein encoded by transcript variant 4 p38 MAP kinase encoded by transcript variant 5 p38 MAP kinase MAP kinase 14 MAP kinase 2 MAP kinase Mxi2 MAP kinase p38 alpha MAPK 14 MAPK14 MAX-interacting protein 2 mitogen-activated protein kinase 14A mitogen-activated protein kinase p38 alpha negative regulator of Crk tyrosine-phosphorylation p38 p38 kinase p38 MAP kinase p38 MAP kinase alpha p38 MAPK p38 mitogen activated protein kinase p38alpha Exip proto-oncogene C-crk reactive kinase SAPK2a CSAIDS binding protein 1 stress-activated protein kinase 2A v-crk avian sarcoma virus CT10 oncogene homolog v-crk sarcoma virus CT10 oncogene homolog v-crk sarcoma virus CT10 oncogene homolog (avian) isoform CRK_1 v-crk sarcoma virus CT10 oncogene homolog (avian) isoform CRK_2 v-crk sarcoma virus CT10 oncogene-like protein