Enables several functions, including phosphatidylinositol-3,4,5-trisphosphate binding activity; protein serine/threonine kinase binding activity; and type I transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular component biogenesis; and positive regulation of intracellular signal transduction. Acts upstream of or within cell adhesion and protein localization to cell junction. Located in several cellular components, including adherens junction; cytoplasmic side of plasma membrane; and focal adhesion. Biomarker of acute myeloid leukemia. [provided by Alliance of Genome Resources, Jul 2025]
Alternative Names
fermitin family member 2 kindlin 2 mitogen inducible 2 mitogen inducible gene 2 protein mitogen inducible gene-2 PH domain-containing family C member 1 pleckstrin homology domain containing family C (with FERM domain) member 1 pleckstrin homology domain containing family C member 1 pleckstrin homology domain-containing family C member 1