| Product Name | Anti-ERBB4 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISA |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | ERBB4 |
|---|---|
| Gene Synonyms | ALS19 c-erbB-4 HER4 p180erbB4 |
| Gene Full Name | erb-b2 receptor tyrosine kinase 4 |
| Gene Summary | This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] |
| Alternative Names | avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4 avian erythroblastosis oncogene B 4 erbB4 human epidermal growth factor receptor 4 OTTHUMP00000209432 proto-oncogene-like protein c-ErbB-4 tyrosine kinase-type cell surface receptor HER4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 |
| Molecular Weight(MW) | 146kDa |
| Source | Rabbit |
| Cellular Localization | Cell membrane;Nucleus;Mitochondrion |
| SwissProt ID | Q15303 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300. |
