WB
Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-TRAF3 (PT1214R) antibody. The HRP-conjugated Goat anti-Rabbit IgG (H + L) antibody was used to detect the antibody. Lane 1: SW620 Lane 2: C2C12 Lane 3: PC-12| Product Name | TRAF3 Rabbit mAb |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Clonality | monoclonal |
|---|---|
| Isotype | IgG,K |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:2000-1:10000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | TRAF3 |
|---|---|
| Gene Synonyms | LAP1 CAP-1 CRAF1 IIAE5 CD40bp RNF118 IMD132A IMD132B |
| Gene Full Name | TNF receptor associated factor 3 |
| Gene Summary | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020] |
| Alternative Names | TRAF3 CAP1 CRAF1 TNF receptor-associated factor 3 CAP-1 CD40 receptor-associated factor 1 CRAF1 CD40-binding protein CD40BP LMP1-associated protein 1 LAP1 |
| Molecular Weight(MW) | 64kDa |
| Cellular Localization | Cytoplasm . Endosome . Mitochondrion . Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity) . Co-localized to mitochondria with TRIM35 (PubMed:32562145) . . |
WB
Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-TRAF3 (PT1214R) antibody. The HRP-conjugated Goat anti-Rabbit IgG (H + L) antibody was used to detect the antibody. Lane 1: SW620 Lane 2: C2C12 Lane 3: PC-12| Application Notes | WB:1:2000-1:10000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Storage Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA. |
