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In vivo Grade Recombinant Anti-mouse TIGIT (Clone: 1F4), Mouse IgG2a Kappa

Catalog Number:OM680058
OM680058
Discount Price
OM680058-1mg
1mg
OM680058-5mg
5mg
OM680058-25mg
25mg
Product Profile
Product Name In vivo Grade Recombinant Anti-mouse TIGIT (Clone: 1F4), Mouse IgG2a Kappa
Product description

Recombinant mouse IgG2a Monoclonal Antibody. 
Clone: 1F4.
Isotype: Mouse IgG2a kappa.
Source: The anti-mouse TIGIT monoclonal antibody (clone: 1F4) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: 1F4) specifically binds to the mouse TIGIT protein.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse TIGIT protein. 
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The antibody is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

Target Information
Function The 1F4 antibody binds to the TIGIT protein (WUCAM, Vstm3 or VSIG9), a novel immune checkpoint receptor with inhibitory function. TIGIT is expressed on T cells and natural killer (NK) cells, and several human cancers, including melanoma, NSCLC, and colorectal cancer. Similar to PD-1, the TIGIT receptor limits antitumor immune response in cancer.
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