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In vivo Grade Recombinant Anti-mouse CD137 (TNFRSF9 or 4-1BB) (Clone: LOB12.3), Rat IgG1 Kappa

Catalog Number:OM680061
OM680061
Discount Price
OM680061-1mg
1mg
OM680061-5mg
5mg
OM680061-25mg
25mg
Product Profile
Product Name In vivo Grade Recombinant Anti-mouse CD137 (TNFRSF9 or 4-1BB) (Clone: LOB12.3), Rat IgG1 Kappa
Product description

Recombinant rat IgG1 Monoclonal Antibody. 
Clone: LOB12.3.
Isotype: Rat IgG1 kappa.
Source: The anti-mouse CD137 (TNFRSF9 or 4-1BB) monoclonal antibody (clone: LOB12.3) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: LOB12.3) specifically binds to the mouse 4-1BB protein.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse 4-1BB protein. 
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The antibody is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

Target Information
Function The LOB12.3 antibody binds to 4-1BB (TNFRSF9 or CD137), one representative TNF receptor family co-stimulatory receptor. The 4-1BB protein is expressed on a wide variety of cell types, including activated T cells, NK cells, DCs, B cells, monocytes, and neutrophils. Anti-4-1BB-induced CD8+ T responses play a dominant role in anti-tumor immunity, such as induction of more effector molecules released from CD8+ T cells, increased proliferation and decreased apoptosis of CD8+ T cells.
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