| Product Name | In vivo Grade Recombinant Anti-mouse CD370, Rat IgG2a Kappa (Clone: 10B4) |
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| Product description | The in vivo grade recombinant anti-mouse CD370 rat IgG2a monoclonal antibody was produced in mammalian cells. Shipping: The in vivo grade recombinant anti-mouse CD370 antibodies (clone of 10B4) are shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| Function | The rat anti-mouse CD370 (Clec9A or DNGR-1) monoclonal antibody 10B4 (rat IgG2a kappa) reacts with the mouse CD370 protein. CLEC9A (C-type lectin domain family 9 member A), a transmembrane glycoprotein with a single extracellular C-type lectin domain (CTLD), plays a role in the immune response. As an activation receptor, CLEC9A is expressed on myeloid lineage cells, helps process material from dead cells, recognizes filamentous actin when cell membranes are damaged, and helps present antigens to cytotoxic T cells. CLEC9A has an intracellular cytoplasmic tail with potential signaling motifs. CLEC9A is expressed on a subset of BDCA3+ dendritic cells and CD16- monocytes in humans, and is expressed on CD8+ conventional DCs and plasmacytoid DCs in mice. Our recombinant 10B4 antibodies have a part (variable regions) or complete amino acid sequences of the rat anti-mouse CD370 monoclonal antibody (hybridoma clone name or number: 10B4). |
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