| Gene Symbol |
OTUB1
|
| Gene Synonyms |
OTB1 OTU1 HSPC263 |
| Gene Full Name |
OTU deubiquitinase, ubiquitin aldehyde binding 1 |
| Gene Summary |
The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| Alternative Names |
Deubiquitinating enzyme OTUB1
hOTU1
HSPC263
OTB1
OTU domain containing ubiquitin aldehyde binding protein 1
OTU domain ubiquitin aldehyde binding 1
OTU domain-containing Ubal-binding protein 1
OTU domain-containing ubiquitin aldehyde-binding protein 1
OTU-domain Ubal-binding 1
OTU1
Otub1
OTUB1_HUMAN
Otubain 1
Otubain-1
Ubiquitin specific processing protease OTUB1
Ubiquitin thioesterase OTUB1
ubiquitin-specific protease otubain 1
Ubiquitin-specific-processing protease OTUB1 |
| Molecular Weight(MW) |
31 kDa |
| Cellular Localization |
Cytoplasm. |