| Gene Symbol |
WASF1
|
| Gene Synonyms |
WAVE SCAR1 WAVE1 WAVE-1 NEDALVS |
| Gene Full Name |
WASP family member 1 |
| Gene Summary |
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| Alternative Names |
WASP family verprolin homology domain-containing protein 1
WASP family member 1
FLJ31482
homology of dictyostelium scar 1
KIAA0269
Protein WAVE-1
Protein WAVE1
scar Dictyostelium homology of 1
SCAR1
Similar to a plant extensin like protein
Verprolin homology domain containing protein 1
Verprolin homology domain-containing protein 1
WAS protein family member 1
Wasf1
WASF1_HUMAN
WASL
WASP family 1
WASP family protein member 1
WASP family verprolin homology domain-containing protein
WAVE
WAVE1
Wiskott Aldrich syndrome protein family member 1
Wiskott-Aldrich syndrome protein family member 1 |
| Molecular Weight(MW) |
62 kDa |
| Cellular Localization |
Cell junction,Cytoplasm,Cytoskeleton,Synapse. |