| Product Name | Anti-Phospho-Cortactin (Tyr421) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Tyr421 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CTTN |
|---|---|
| Gene Synonyms | EMS1 |
| Gene Full Name | cortactin |
| Gene Summary | This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010] |
| Alternative Names | Amplaxin antibody CTTN antibody EMS 1 antibody EMS1 antibody FLJ34459 antibody Mammary tumor and squamous cell carcinoma associated antibody Oncogene EMS1 antibody p80/85 src substrate antibody Src substrate cortactin antibody SRC8_HUMAN antibody |
| Molecular Weight(MW) | 62 kDa |
| Cellular Localization | Cell junction,Cell membrane,Cell projection,Coated pit,Cytoplasm,Cytoskeleton,Endoplasmic reticulum,Membrane,Synapse. |
| SwissProt ID | Q14247 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
