| Gene Symbol |
CDKN1C
|
| Gene Synonyms |
BWS WBS p57 BWCR KIP2 p57Kip2 |
| Gene Full Name |
cyclin dependent kinase inhibitor 1C |
| Gene Summary |
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] |
| Alternative Names |
Beckwith Wiedemann syndrome BWCR BWS CDKI CDKN 1C CDKN1C CDN1C_HUMAN Cyclin dependent kinase inhibitor 1C Cyclin dependent kinase inhibitor p57 Cyclin-dependent kinase inhibitor 1C Cyclin-dependent kinase inhibitor p57 KIP 2 KIP2 p57 p57 Kip 2 p57KIP2 WBS |
| Molecular Weight(MW) |
32 kDa |
| Cellular Localization |
Nucleus. |