| Gene Symbol |
GRK2
|
| Gene Synonyms |
BARK1 ADRBK1 BETA-ARK1 |
| Gene Full Name |
G protein-coupled receptor kinase 2 |
| Gene Summary |
This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017] |
| Alternative Names |
ADRBK1 Adrenergic beta receptor kinase 1 ARBK1_HUMAN BARK BARK1 Beta adrenergic receptor kinase 1 Beta ARK 1 Beta ARK1 Beta-adrenergic receptor kinase 1 Beta-ARK-1 FLJ16718 G protein coupled receptor kinase 2 G-protein coupled receptor kinase 2 GRK2 |
| Molecular Weight(MW) |
80 kDa |
| Cellular Localization |
Cell membrane,Cell projection,Cytoplasm,Membrane,Synapse. |