| Product Name | Anti-Phospho-Nephrin (Tyr1217) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Tyr1217 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NPHS1 |
|---|---|
| Gene Synonyms | CNF NPHN nephrin |
| Gene Full Name | NPHS1 adhesion molecule, nephrin |
| Gene Summary | This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009] |
| Alternative Names | CNF Nephrin Nephrosis 1 congenital Finnish type Nephrosis 1 congenital Finnish type (nephrin) NPHN NPHN_HUMAN NPHS 1 Nphs1 Renal glomerulus specific cell adhesion receptor Renal glomerulus-specific cell adhesion receptor |
| Molecular Weight(MW) | 135 kDa |
| Cellular Localization | Cell membrane,Membrane. |
| SwissProt ID | O60500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
