| Gene Symbol |
GRIN2A
|
| Gene Synonyms |
LKS EPND FESD NR2A GluN2A NMDAR2A |
| Gene Full Name |
glutamate ionotropic receptor NMDA type subunit 2A |
| Gene Summary |
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| Alternative Names |
EPND FESD GluN2A Glutamate [NMDA] receptor subunit epsilon-1 Glutamate receptor Glutamate receptor ionotropic N methyl D aspartate 2A GRIN 2A GRIN2A hNR2A LKS N methyl D aspartate receptor channel subunit epsilon 1 N Methyl D Aspartate Receptor Subtype 2A N methyl D aspartate receptor subunit 2A N-methyl D-aspartate receptor subtype 2A NMDA receptor subtype 2A NMDAR 2A NMDAR2A NMDE1_HUMAN NR2A OTTHUMP00000160135 OTTHUMP00000174531
|
| Molecular Weight(MW) |
165 kDa |
| Cellular Localization |
Cell membrane, postsynaptic cell membrane, dendritic spine, synapse, Cytoplasmic vesicle membrane. |