| Gene Symbol |
YBX1
|
| Gene Synonyms |
YB1 BP-8 CSDB DBPB YB-1 CBF-A CSDA2 EFI-A NSEP1 NSEP-1 MDR-NF1 |
| Gene Full Name |
Y-box binding protein 1 |
| Gene Summary |
This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015] |
| Alternative Names |
BP 8 CBF-A CCAAT binding transcription factor I subunit A CCAAT-binding transcription factor I subunit A CSDA2 CSDB DBPB DNA binding protein B DNA-binding protein B EFI-A Enhancer factor I subunit A MDR NF1 MGC104858 MGC110976 MGC117250 NSEP 1 NSEP1 Nuclease sensitive element binding protein 1 Nuclease-sensitive element-binding protein 1 p50 Q15905 Y-box binding protein 1 Y-box transcription factor Y-box-binding protein 1 YB 1 YB-1 YBOX1_HUMAN YBX 1 ybx1
|
| Molecular Weight(MW) |
36 kDa |
| Cellular Localization |
Cytoplasm, Nucleus, Cytoplasmic granule, Secreted. |