| Gene Symbol |
JAK3
|
| Gene Synonyms |
JAKL LJAK JAK-3 L-JAK JAK3_HUMAN |
| Gene Full Name |
Janus kinase 3 |
| Gene Summary |
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008] |
| Alternative Names |
EC 2.7.10.2 JAK 3 JAK L JAK-3 Jak3 JAK3 HUMAN JAK3_HUMAN JAKL Janus kinase 3 (a protein tyrosine kinase leukocyte) Janus kinase 3 Janus Kinase3 L JAK L-JAK Leukocyte janus kinase LJAK Protein tyrosine kinase leukocyte Tyrosine protein kinase JAK3 Tyrosine-protein kinase JAK3
|
| Molecular Weight(MW) |
125 kDa |
| Cellular Localization |
Endomembrane system, Cytoplasm. |