| Product Name | Anti-Phospho-ACTN1/2/3/4 (Ser159) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser159 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ACTN1/ACTN2/ACTN3/ACTN4 |
|---|---|
| Gene Synonyms | BDPLT15 MPD6 CMH23 CMYO8 CMYP8 CMD1AA MYOCOZ ACTN3D FSGS FSGS1 ACTININ-4 |
| Gene Full Name | actinin alpha 1/2/3/4 |
| Gene Summary | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Alternative Names | actinin 4 Actinin alpha 4 actinin4 ACTN 4 ACTN4 ACTN4_HUMAN Alpha-actinin-4 DKFZp686K23158 F actin cross linking protein F-actin cross-linking protein Focal segmental glomerulosclerosis 1 FSGS 1 FSGS FSGS1 Non muscle alpha actinin 4 Non-muscle alpha-actinin 4 actinin 1 smooth muscle Actinin alpha 1 actinin alpha 1 ACTN 1 Actn1 ACTN1_HUMAN Alpha Actinin 1 Alpha actinin cytoskeletal isoform Alpha-actinin cytoskeletal isoform Alpha-actinin-1 BDPLT15 F actin cross linking protein F-actin cross-linking protein FLJ40884 FLJ54432 Non muscle alpha actinin 1 Non-muscle alpha-actinin-1 Actin binding protein Actinin alpha 2 ACTN 2 ACTN2 ACTN2_HUMAN Alpha actinin 2 Alpha actinin skeletal muscle Alpha actinin skeletal muscle isoform 2 Alpha-actinin skeletal muscle isoform 2 Alpha-actinin-2 CMD1AA F actin cross linking protein F-actin cross-linking protein Actinin alpha 3 actinin alpha ACTN 3 ACTN3 ACTN3_HUMAN Alpha actinin skeletal muscle Alpha actinin skeletal muscle |
| Molecular Weight(MW) | 103 kDa,104 kDa,105 kDa |
| Cellular Localization | Cell junction, Cell membrane, Cell projection, Cytoplasm, Plasma membrane. Cytoskeleton.Nucleus. |
| SwissProt ID | P12814/P35609/Q08043/O43707 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
