| Product Name | Anti-Phospho-JIP1 (Thr205) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Thr205 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | MAPK8IP1 |
|---|---|
| Gene Synonyms | IB1 JIP1 JIP-1 PRKM8IP |
| Gene Full Name | mitogen-activated protein kinase 8 interacting protein 1 |
| Gene Summary | This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011] |
| Alternative Names | C jun amino terminal kinase interacting protein 1 C-jun-amino-terminal kinase-interacting protein 1 IB 1 IB-1 IB1 Islet brain 1 Islet-brain 1 JIP 1 JIP-1 JIP1_HUMAN JNK interacting protein 1 JNK MAP kinase scaffold protein 1 JNK-interacting protein 1 MAPK8IP 1 MAPK8IP1 MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 Mitogen activated protein kinase 8 interacting protein 1 Mitogen-activated protein kinase 8-interacting protein 1 PRKM8 PRKM8 interacting protein PRKM8IP |
| Molecular Weight(MW) | 78 kDa |
| Cellular Localization | Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Nucleus (By similarity). Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus |
| SwissProt ID | Q9UQF2 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
