| Product Name | Anti-Phospho-SHC(Tyr427) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Tyr427 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SHC1 |
|---|---|
| Gene Synonyms | SHC SHCA |
| Gene Full Name | SHC adaptor protein 1 |
| Gene Summary | This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] |
| Alternative Names | FLJ26504 p66 p66SHC SH2 domain protein C1 SHC (Src homology 2 domain containing) transforming protein 1 SHC 1 SHC A SHC adaptor protein 1 Shc SHC transforming protein 1 SHC transforming protein SHC-transforming protein 1 SHC-transforming protein 3 SHC-transforming protein A SHC1 SHC1_HUMAN SHCA Src homology 2 domain-containing-transforming protein C1 |
| Molecular Weight(MW) | 63 kDa |
| Cellular Localization | Cell junction, Cytoplasm, Mitochondrion |
| SwissProt ID | P29353 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
