| Gene Symbol |
ROR1
|
| Gene Synonyms |
NTRKR1 dJ537F10.1 |
| Gene Full Name |
ROR family WNT receptor 1 |
| Gene Summary |
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012] |
| Alternative Names |
dJ537F10.1 Inactive tyrosine protein kinase transmembrane receptor ROR1 MGC99659 Neurotrophic tyrosine kinase Neurotrophic tyrosine kinase receptor related 1 Neurotrophic tyrosine kinase receptor related 1 NTRKR1 OTTHUMP00000010573 OTTHUMP00000010574 OTTMUSP00000008344 Receptor tyrosine kinase like orphan receptor 1 receptor-related 1 RGD1559469 ROR 1 ROR1 ROR1_HUMAN RP11 24J23.1 Tyrosine kinase like orphan receptor 1 Tyrosine protein kinase transmembrane receptor ROR1 Tyrosine-protein kinase transmembrane receptor ROR1
|
| Molecular Weight(MW) |
104 kDa |
| Cellular Localization |
Cell membrane, Cell projection, axon |