| Gene Symbol |
RAB8A
|
| Gene Synonyms |
MEL, RAB8 |
| Gene Full Name |
RAB8A, member RAS oncogene family |
| Gene Summary |
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008] |
| Alternative Names |
Rabbit IgG in phosphate buffered saline
pH 7.4
150mM NaCl
0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt. |
| Molecular Weight(MW) |
24 kDa |
| Cellular Localization |
Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Golgi apparatus, Lysosome, Membrane |
