| Product Name | Anti-Phospho-MeCP2 (Ser423) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser423 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | MECP2 |
|---|---|
| Gene Synonyms | RS RTS RTT PPMX MRX16 MRX79 MRXSL AUTSX3 MRXS13 |
| Gene Full Name | methyl-CpG binding protein 2 |
| Gene Summary | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015] |
| Alternative Names | AUTSX 3 AUTSX3 DKFZp686A24160 Mbd 5 Mbd5 MECP 2 MeCP 2 protein MeCP-2 protein Mecp2 MECP2_HUMAN Methyl CpG binding protein 2 (Rett syndrome) Methyl CpG binding protein 2 Methyl-CpG-binding protein 2 MRX 16 MRX 79 MRX16 MRX79 MRXS 13 MRXS13 MRXSL PPMX RS RTS RTT WBP 10 WBP10 |
| Molecular Weight(MW) | 52 kDa |
| Cellular Localization | Nucleus |
| SwissProt ID | P51608 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
