| Product Name | Anti-Phospho-RPA32/RPA2 (Ser4/Ser8) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser4/Ser8 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | RPA2 |
|---|---|
| Gene Synonyms | REPA2 RPA32 RP-A p32 RP-A p34 |
| Gene Full Name | replication protein A2 |
| Gene Summary | This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017] |
| Alternative Names | 60S acidic ribosomal protein P1 AA409079 AI325195 AU020965 ik:tdsubc_2g1 M(2)21C MGC137236 OTTHUMP00000004008 p32 p34 RCJMB04_6d17 replication protein A2 32kDa REPA2 Replication factor A protein 2 Replication protein A 32 kDa subunit Replication protein A 32kDa subunit Replication protein A 34 kDa subunit Replication protein A Replication Protein A2 (32kDa) Replication protein A2 Replication protein A2 32kDa RF-A protein 2 Rf-A2 RFA RFA2_HUMAN RP-A p32 RP-A p34 RP21C RPA 2 RPA 32 RPA Rpa2 RPA32 RPA34 RpLP1 RpP2 xx:tdsubc_2g1 zgc:109822 |
| Molecular Weight(MW) | 29 kDa |
| Cellular Localization | Nucleus |
| SwissProt ID | P15927 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
