| Product Name | Anti-Phospho-CRYAB (Ser59) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser59 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CRYA8 |
|---|---|
| Gene Synonyms | MFM2 CRYA2 CTPP2 HSPB5 MFM2A MFM2B CMD1II CTRCT16 HEL-S-101 |
| Gene Full Name | crystallin alpha B |
| Gene Summary | Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2019] |
| Alternative Names | AACRYA Alpha B crystallin Alpha crystallin B chain Alpha(B)-crystallin Alpha-crystallin B chain CRYA2 Cryab CRYAB_HUMAN Crystallin alpha B Crystallin alpha polypeptide 2 CTPP2 Heat shock 20 kD like protein Heat shock protein beta 5 Heat shock protein beta-5 HspB5 Renal carcinoma antigen NY REN 27 Renal carcinoma antigen NY-REN-27 Rosenthal fiber component |
| Molecular Weight(MW) | 20 kDa |
| Cellular Localization | Cytoplasm, Lysosome, Nucleus, Secreted |
| SwissProt ID | P02511 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
