| Gene Symbol |
BAD
|
| Gene Synonyms |
BBC2 BCL2L8 |
| Gene Full Name |
BCL2 associated agonist of cell death |
| Gene Summary |
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large) and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019] |
| Alternative Names |
AI325008 BAD BAD_HUMAN BBC 2 BBC2 BBC6 Bcl 2 Antagonist of Cell Death Bcl 2 Binding Component 6 BCL X / BCL 2 Binding Protein BCL X Binding Protein Bcl XL/Bcl 2 Associated Death Promoter Bcl-2-binding component 6 Bcl-2-like protein 8 Bcl-XL/Bcl-2-associated death promoter Bcl2 antagonist of cell death BCL2 antagonist of cell death protein BCL2 associated agonist of cell death Bcl2 Associated Death Promoter BCL2 binding component 6 BCL2 binding protein Bcl2 Like 8 Protein Bcl2-L-8 BCL2L8 Proapoptotic BH3 Only Protein |
| Molecular Weight(MW) |
18 kDa |
| Cellular Localization |
Cytoplasm,Membrane,Mitochondrion,Mitochondrion outer membrane. |