| Product Name | Anti-Phospho-MDM2 (Ser186/Ser188) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser186/Ser188 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | MDM2 |
|---|---|
| Gene Synonyms | HDMX LSKB hdm2 ACTFS |
| Gene Full Name | MDM2 proto-oncogene |
| Gene Summary | This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013] |
| Alternative Names | ACTFS Double minute 2 protein E3 ubiquitin-protein ligase Mdm2 Hdm 2 Hdm2 HDMX MDM 2 MDM2 MDM2 oncogene E3 ubiquitin protein ligase Mdm2 p53 E3 ubiquitin protein ligase homolog Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa MDM2_HUMAN MDM2BP Mouse Double Minute 2 MTBP Murine Double Minute Chromosome 2 Oncoprotein Mdm2 p53 Binding Protein Mdm2 p53-binding protein Mdm2 Ubiquitin protein ligase E3 Mdm2 Ubiquitin protein ligase E3 Mdm2 |
| Molecular Weight(MW) | 55 kDa |
| Cellular Localization | Cytoplasm,Nucleus. |
| SwissProt ID | Q00987 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
